Entrepreneurs and their upstart companies are challenging the health care industry’s high costs, frequent lack of transparency, and outdated processes. These innovators are responding to opportunities created by artificial intelligence, internet-based technologies, and regulatory pressure to provide value-based, outcome-driven care on an individual level. Silicon Flatirons recently convened providers, upstart firms, academic institutions, and governmental officials to discuss building a great health care innovation ecosystem. A Flatirons Report was produced as a result.